TNF-A

TNF-α is a potent immune-mediator and pro-inflammatory cytokine. TNF-α plays a powerful role in regulating inflammatory pathways. Chronic low-grade systemic inflammation has been introduced as a term for conditions in which there is a two- to three-fold increase in the systemic concentrations of several cytokines. The inflammatory state is a major component of obesity and its associated comorbidities, such as CVD, T2DM, Alzheimer's Disease, and several cancers.

In addition, increased production of TNF-α is a crucial mediator of insulin resistance (IR), inflammatory bowel disease, dyslipidemia, and rheumatoid arthritis. Genetic variations in the TNFA gene may affect TNF-α transcription and expression, influencing the development of conditions associated with increased TNF-α production. Dietary factors, such as fatty acids, interact with TNFA gene variants and modulate the development and progression of inflammatory-related conditions.

If you have the A-allele carrier status in this gene, then you are predisposed to increase TNF-α transcription two-fold, with a subsequent increase in TNF-α production. This has been associated with low-grade, chronic inflammation, and associated conditions. Specifically, with overweight and obesity, insulin resistance, inflammatory bowel disease, dyslipidemia, and all arthritis conditions.

The following nutrients/minerals act as cofactors for the down-regulation of TNF-a or are impacted by high TNF-a levels: Vitamin C (high TNF-A decreases the absorption of vitamin C), butyrate (high TNF-A decreases transporters for butyrate), phosphate (absorption is decreased when TNF-alpha is high. CoQ10, berberine, alpha-lipoic acid, astaxanthin, citrulline, ginkgo, NAC, theanine, cinnamon, CBD oil and zinc all act as powerful nutrient co-factors for TNF-a regulation. Low phosphate absorption can cause problems with teeth and bones), rosmarinic acid, curcumin, probiotics (Bifidobacteria or Lactobacillus), resveratrol, low magnesium levels may play a role in higher TNF-alpha levels and should be supplemented if dietary intake is insufficient and omega-3 is anti-inflammatory. It's a good idea to reduce linoleic and arachidonic acid in your diet and increase omega 3 intake.

When personalising your health choices, it is important to consider your IL-1, IL-6, and APOE  genotypes.