DNA | Health + Mind

NAPPI CODE:

DNALYSIS

We believe that more medical info is better than less. Combining our genetic tests to best suit your needs gives you more info plus works out more cost effective.

DNA | Health

DNA | Health is great foundation test to combine with one of our other DNA tests. It can help you better understand your health risks and how to prevent them. 

The 8 key areas that could lead to a chronic illness that this test looks at:

  • Lipid Metabolism: High cholesterol potential and whether medication will help reduce raised cholesterol  
  • DNA Methylation: potential DNA damage risks
  • Detoxification: key enzymes needed for effective detoxification
  • Inflammation: inflammation, along with oxidative stress, are 2 key markers for almost all chronic illnesses
  • Oxidative stress: this can lead to premature ageing, both inside and outside of your body
  • Bone health: Osteoporosis
  • Insulin sensitivity: risk of blood sugar and insulin imbalance risks associated with a wide variety including diabetes
  • Food responsiveness and sensitivity: lactose intolerance, caffeine processing, salt sensitivity and blood pressure and iron overload disorders 

Armed with this invaluable information, you can eliminate future health risks by carefully planning a life-long diet, exercise, supplement and general wellbeing plan that works to keep at bay the diseases to which you are susceptibly. 

    DNA | Mind

    DNA Mind tests for genetic variations associated with changes in key biological areas that affect mental health. Weaknesses in these areas, together with environmental factors, increase risk for development of disorders related to mental health. The areas of mental health reported in DNA Mind include: Neurodegenerative disorders, mood disorders, and addictive behaviour.

    TESTS FOR 
    Neurodegenerative disorders

    Mild cognitive impairment (MCI) causes a slight, but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Individuals with mild cognitive impairment are at an increased risk of developing Alzheimer’s Disease (AD) or another dementia. Altered functioning of specific biological areas has been related to increased risk of MCI as well as late-onset AD.

    The genes analysed are APOE, CRP, IL-1, IL-6, TNFA, COMT, BDNF which are involved in either lipid metabolism, inflammation, dopaminergic and neurotrophic processes. 

    Mood disorders

    Mood disorders are psychological disorders that are characterized by the elevation or lowering of an individual’s mood, to the extent that it can interfere with everyday life for an extended period of time. The specific mood disorders reported include bipolar, depression, anxiety and post-traumatic stress disorder.

    The genes associated with mood disorders include CRP, IL-1, IL-6, TNFA, MTHFR, MTR, COMT, BDNF, 1A HTR1A, FKBP5, OXTR, CACNA1C, ANK3, GSK3B and are analysed as part of inflammation, methylation, dopaminergic, neurotrophic, serotonergic, stress response, cell signalling and WNT signalling. 

    Addictive behaviours:

    Addictive behaviour can manifest in a number of disorders, which are complex in their aetiology and are influenced by both genetic and environmental factors. Genetics and addictive areas of the association include behavioural disorders such as eating disorders (binge eating), ‘adrenaline seeking’, and risk-taking behaviour. Substance use disorders include risk of alcohol, nicotine, cannabis and opioid dependence. This area will also report on psychosis response from cannabis use.

    The genes associated with addictive behaviours are CHRNA3, CHRNA5, CNR1, FAAH, AKT1, DRD1, DRD2, DRD3, DRD4, COMT, OPRM1, BDNF, SLC6A4 and GABRA2. These genes are involved in cell signalling, endocannabinoid, dopaminergic, neurotrophic, serotonergic and stress response processes. 

    Sample required 

    Buccal (cheek) lining swab - this is just a simple, painless firm rub with a long earbud (the swab) on the inside of your cheek. 

    Average processing time 

    Around 14 working days  

    Sample reports

    The science behind these DNA reports

    Once the DNAlysis lab receives your DNA sample, they use a process called Polymerase Chain Reaction (PCR) to copy the DNA in your genes many times over, so that they have ample material with which to analyse your genetic material. They then look for unique DNA sequences in your genes, and if they spot changes from the norm, they mark those as risk factors.

    Understanding genetics

    It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.

    At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health.

    Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

    What are genes?

    Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

    What are gene variations?

    An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a 'Single Nucleotide Polymorphism', or 'SNP' (pronounced “snip”).

    Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits. 

    Are gene variations bad?

    In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.