DNA | Coeliac (Genetic gluten sensitivity)

NAPPI CODE:

DNALYSIS

Coeliac disease (CD) is a common, autoimmune disorder affecting about 1% of the population, in which the small intestine is damaged in response to a severe gluten intolerance. 

People who test positive for HLA variants have a significantly greater chance of developing coeliac disease when on a diet high in gluten. Having these gene mutations are associated with coeliac disease.

The benefit of ordering this test from MY DNA CHOICES.

The feedback session is included in the cost of the test.

Test type

A genetic test that that analyses your 'Human Leukocyte Antigen' (HLA) gene to see whether or not you have a genetic variation that would predispose you to a severe gluten intolerance that has a genetic cause. 

Benefits | Features

  • Suitable for all ages
  • Tests for severe gluten intolerances
  • Severe intolerance could lead to malnutrition, inflammation or Celiac disease
  • Make informed decisions about your diet
  • Easy home saliva test
  • Simple saliva swab
  • Takes 30 seconds to do
  • No doctor’s appointment
  • Analyses your DNA and genes
  • Genetic test detects DNA variations which indicate risk
  • Trusted by parents and dieticians internationally
  • Counselling Services
  • All tests include 6-8 free counselling services with a counsellor from ICAS
  • You might also find it useful to see you doctor or genetic counsellor with your results.
  • Comfortable
  • Convenient
  • No time off work
  • More accurate
  • Lab analysed

Sample report

What if my results are negative?

If you do the test, receive a negative result but you still have symptoms, please see your doctor as soon as possible.

Gene variation not detected

What do these results mean?

Certain genes in our bodies put us at an increased risk for certain conditions. The genes which put you at risk for the gluten intolerances was not found in your sample.

What do I do next? 

Your risk is low for celiac disease, however, if you are experiencing symptoms such as diarrhoea, digestion problems, abnormal excretion or weight loss, it is recommended that you visit a dietician or nutritionist for a more thorough examination and consultation.

Gene variation detected

What do these results mean?

Celiac disease could be the end result of being severely gluten intolerant. It is a T-cell-mediated autoimmune disease of the small intestine which can be detected genetically. If certain genes are detected, they may put an individual at a significant risk when gluten is included in the diet, but it does not mean that one will develop celiac disease long-term.

What do I do next?

We recommend making an appointment with your nutritionist or dietician, who can assist you with a more thorough consultation, specific evaluation and recommendations specific to you. It is recommended that you print out your lab report and take it with you.

MY DNA CHOICES. like

If you get a positive result for this test, then you most likely have a sensitivity to gluten. About 40% of people carry the HLA-DQ2 and HLA-DQ8 genes, which makes them susceptible to gluten sensitivity or gluten intolerance. This means that when you are exposed to gluten, either through diet, body products or other means, you are very likely to experience abdominal and joint pain, bloating, stool inconsistency (constipation and/or diarrhoea), brain fog, mood changes, concentration issues and fatigue, among other symptoms. There are studies showing that gluten can cause inflammation of the intestines and a degenerated intestinal lining reducing the barrier function of the intestine and resulting in a 'leaky gut'. Th which allows unwanted substances to “leak” through into the bloodstream. Irritable bowel syndrome (IBS) involves various digestive issues with unknown causes. According to the studies, some cases of IBS may be either caused or exacerbated by gluten.

More info

The literature suggests that FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols) and not gluten per se are the triggers of gastrointestinal symptoms in patients that fit most of the proposed non-coeliac gluten sensitivity (NCGS) definitions. Interestingly, wheat, rye, and barley are food sources of FODMAPs and should be avoided in FODMAP sensitive individuals. Diagnosis of “NCGS” should only occur after coeliac disease, wheat allergies, and other inflammatory disorders have been ruled out, including sensitivity to non-gluten food constituents from wheat that can trigger gastrointestinal symptoms.

Instructions

  1. No eating or drinking for 2 hrs before doing the test or do the test on waking
  2. Wash your hands
  3. Remove the 'earbud-like' swab from the tube - take care not to touch the white swab head with your fingers as this will contaminate your DNA sample
  4. Insert the swab into your mouth and rub firmly against the inside of your cheek for 1 minute with firm pressure
  5. Place the swab back into the tube being careful not touch the swab head with your fingers
  6. Seal the tube securely with its caps
  7. Place the packaging in the discreet bag provided and seal it
  8. Book the courier collection

Sample required

Buccal (cheek) lining swab - this is just a simple, painless firm rub with a long earbud (the swab) on the inside of your cheek. 

Average processing time

Around 14 working days

Understanding genetics

It may sound like something out of a sci-fi movie, but genetic testing is a powerful health tool that can give you a deep understanding of how your body works.

At the heart of it is the molecule DNA. Every single cell in our bodies – from our heart to skin, blood and bone – contains a complete set of our DNA. This powerful molecule carries our genetic code and determines all manner of traits, from our eye colour to aspects of our personalities and, of course, our health.

Interestingly, 99.9% of the DNA from two people is identical. It’s the other 0.1% of DNA code sequences that make us unique.

What are genes?

Genes are segments of DNA that contain the instructions your body needs to make each of the many thousands of proteins required for life. Each gene is comprised of thousands of combinations of ‘letters’ which make up your genetic code. The code gives the instructions to make the proteins required for proper development and function.

What are gene variations?

An example of a genetic variation is that one ‘letter’ may be replaced by another. These variations can lead to changes in the resulting proteins being made. For example, a ‘C’ may be changed to a ‘G’ at a point in the genetic code. When the variation affects only one genetic ‘letter’ it is called a 'Single Nucleotide Polymorphism', or 'SNP' (pronounced “snip”).

Variations can however also affect more than one ‘letter’. Genetic tests look at specific chromosomes, genes or proteins, and the variations that occur within them, to make observations about disease or disease risk, body processes or physical traits. 

Are gene variations bad?

In general, variations should not be considered good or bad. Rather, genetic variations are simply slight differences in the genetic code. The key is to know which form of the variation you carry so that you can make appropriate lifestyle choices. And that is the beauty of genetic testing. It can tell you more about the way you're built so that you can tailor your lifestyle to fit your biology.