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The Angiotensin 1 converting enzyme (ACE) gene codes for the ACE protein and is part of the renin-angiotensin system (RAS), which controls blood pressure by regulating fluid volume in the body.

The ACE gene variant also contributes to salt sensitivity. An ACE gene polymorphism associated with an increased ACE activity might be associated with the atherosclerotic process and consequently cardiovascular disease and mortality. It also plays a role in your endurance and performance potential, fat cell growth and differentiation, weight gain and obesity, blood sugar balance, and insulin sensitivity. 

if you have an insertion in this gene, you are likely to have salt-sensitive hypertension. You also have the potential for endurance training and performance. When considering your daily health choices, it is important for you to take a polygenic view and consider your genotype for ACTN3, PPARA, PPARGC1A, VEGF, and AGT

If you present with a deletion, you will be less likely to be predisposed to salt-sensitive hypertension. This genotype indicates a predisposition towards power and strength training and performance. This result has also been associated with increased risk of developing coronary artery disease, increased risk for overweight and obesity, decreased insulin sensitivity, and impaired glucose tolerance. When making daily health choices, it is important for you to consider your results for  ACTN3, PPARA, PPARGC1A, VEGF, and AGT genotypes. 

Some results will indicate that the G allele as the risk genotype. Co-enzyme Q10 and zinc are considered to provide co-factor support to this pathway.