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AGER codes for the receptor for advanced glycation end products—a protein called RAGE. RAGE is a type of immunoglobulin, an immune protein that binds to other proteins and activates the immune response.

sRAGE comes in two forms: a receptor that sits on cells and soluble RAGE (sRAGE), which circulates in the bloodstream. RAGE is produced at the highest levels in the lung compared to other tissues. RAGE levels have been linked to many diseases, including diabetes, autoimmunity, cancer, heart disease, and respiratory disease. Broadly speaking, RAGE appears to cause inflammation of the blood vessels, predisposing them to atherosclerosis, additional inflammation, and extensive damage. sRAGE tends to play a role in chronic inflammatory conditions rather than short-term diseases, though it has been linked to acute respiratory distress syndrome in patients receiving intensive care.

The TT genotype is associated with an increased soluble RAGE expression. If you carry this risk allele then it may be a good idea to eat a diet high in NAC (N-acetylcysteine), omega 3, zinc, and ginger.