The APOA5 gene plays an important role in the regulation of plasma triglycerides (plasma triglycerides are a part of the cholesterol profile that is obtained by your doctor). Triglycerides are fatty molecules constructed of three fatty acid chains attached to a sugary backbone. Triglycerides are also normally found circulating in the blood with other fatty molecules such as cholesterol.
If you carry the C-allele in this gene, then you'll be predisposed to reduced APOA5 concentration and activity. This genetic variation has been associated with increased triglyceride levels and decreased HDL (good cholesterol). It is important for you to be aware that you have a great risk for hypertriglyceridemia when you consumer cholesterol promoting food. You can provide optimal support to this genetic pathway by reducing cholesterol and linoleic acid (LA) and adding in omega-3. When developing your daily health plan, it would be a good idea to consider your APOE, APOC3, LPL, CETP genotypes too.