The APOC3 gene is a member of the APOA1/C3/A4/A5 gene cluster and is known to play a functional role in lipid and triglyceride metabolism. However, it is regulated by insulin. As a result, APOC3 shows us a potential link between glucose metabolism and lipid metabolism. ApoC3 inhibits lipoprotein lipase (LPL), promotes VLDL production, and slows hepatic VLDL uptake.
If you carry the G-allele in this gene, then you'll be predisposed to greater transcriptional activity leading to higher plasma apoc3 levels. This genetic variation is considered a candidate gene for dyslipidemia and CVD risk. When putting together your daily health choices it is important for you to consider your APOE, APOA5, LPL, and CETP genotypes too.