The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream.
The APOE polymorphisms have been shown to impact blood lipid levels, biomarkers of oxidative stress and chronic inflammation. Beyond lipid and cholesterol metabolism, APOE also modulates aspects of ageing in the brain and artery walls.
If you carry the E2/E2 genetic variation, then you carry the most effective anti-oxidative and anti-inflammatory capacity of the APOE genetic variations. This genetic variation indicates protection against the development of cognitive decline and Alzheimer's disease.
If you have the E2/E3 allele, then effective anti-oxidative and anti-inflammatory capacity of the APOE isoforms may protect against the development of cognitive decline and Alzheimer disease
If you carry the E2/E4 genetic variation, then you need to be aware that the E4 is proinflammatory and promotes oxidative stress. It's important to note that the E4 genotype is associated with cognitive decline, Alzheimer disease, and ageing despite the presence of E2 allele. It is important for you to make daily health choices that reduce chronic inflammation, and maintain brain activity. When putting together your daily health protocol, it is important for you to consider your MnSOD, GPX, CAT, IL, HO-1, and TNFA genotypes too.
If you carry the E3/E4, then you need to be aware that the E4 is proinflammatory and promotes oxidative stress. E4 Associated with higher total and blood LDL cholesterol (bad cholesterol) and greater coronary disease, cognitive decline, and Alzheimer's disease. It is important for you to focus on reducing chronic inflammation, maintain brain activity and include adequate exercise. When honing your health choices, it is important for you to consider MnSOD, GPX, CAT, HO-1, IL and TNFA genotypes too.
If you carry the E4/E4 allele, you need to be aware that E4 is associated with higher total and blood LDL cholesterol (bad cholesterol), greater coronary disease, cognitive decline, Alzheimer's disease, and ageing. It is important for you to focus on reducing chronic inflammation, maintain brain activity and include adequate exercise. When honing your health choices, it is important for you to consider MnSOD, GPX, CAT, HO-1, IL and TNFA genotypes too.
