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The COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera). Type I collagen is the most abundant form of collagen in the human body.

If you have a medium to high impact variation in this gene it is advisable to ensure adequate nutrition to provide optimal support to its functioning together with load-bearing exercises to maintain adequate bone mineral density.