CRP encodes the pro-inflammatory marker C-reactive protein which assists in binding foreign and damaged cells enhances phagocytosis by macrophages. Macrophages use the process of phagocytosis to engulf particles and then digest them. This is an important part of the immune regulation. In short, it flags bacteria and dead cells for clearance as well as upregulates IL-6 cytokine production.
It is involved in several host defence-related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during the acute phase response to tissue injury, infection, or other inflammatory stimuli.
Raised plasma CRP levels are implicated as a marker of systemic low-grade inflammation and may predict an increased risk of inflammatory conditions such as CVD, atrial fibrillation, Alzheimer ́s disease, certain cancers, and type 2 diabetes.
If you carry the G-allele then you would be predisposed to have higher CRP levels, increased inflammatory profile. This genotype has been associated with hypercholesterolemia, adiposity, chronic diseases, autoimmune diseases, and certain cancers. A diet or supplementation that includes omega 3 and PQQ can provide micronutrient support to this genotype. If you carry the A-allele then you will present with 20% lower CRP levels compared to G-allele carriers. The inflammatory profile is even lower when n-3 fatty acid levels were greater than the norm.