CYP1A1
CYP1A1 encodes for the Cytochrome P450 Family 1 Subfamily A Member 1 enzyme. Its biochemical function is to metabolise several drugs and compounds widely used in pharmacotherapy or present in diets. In addition, CYP1A1 is involved in the oxidative metabolism of estrogens, which may play a critical role in the etiology of breast and prostate cancer. If you have a medium to high impact mutation on this gene, you can 'add' in these products to better support the function and processes involved in this genetic pathway.
The CYP1A1 gene encodes a phase I cytochrome P450 enzyme, which is one of the main extra-hepatic enzymes that have the ability to metabolize both exogenous and endogenous compounds into their carcinogenic derivatives. It converts environmental pro-carcinogens such as polycyclic aromatic hydrocarbons (PAHs) and aromatic amines to reactive intermediates having carcinogenic effects. In addition, CYP1A1 is involved in the oxidative metabolism of estrogen, melatonin, and inflammatory mediators.
CYP1A1 Ile462Val (A>G) & CYP1A1 Msp T>C
The CYP1A1 Ile462Val SNP change from A to G leads to an amino acid substitution (ile>val) of its protein and increased enzymatic activity. The association between this SNP and cancer has been well documented.
The CYP1A1 Msp T>C is a functional polymorphism of which the C allele has been associated with increased transcript half-life and an increase in enzyme activity, leading to elevated levels of activated metabolites such as PAHs, and subsequently, DNA damage. Many association studies have reported that this SNP increases the development of several types of cancer, especially amongst smokers.
CYP1A1 Ile462Val G allele & CYP1A1 Msp T>C C allele
The variant G allele of the CYP1A1 Ile462Val SNP and the C allele of the CYP1A1 Msp T>C SNP increases enzyme activity resulting in increased rates of carcinogen activation and subsequently DNA damage. In the presence of the G allele, it is important to reduce exposure to all diet and environmental pro-carcinogens such as PAHs, aromatic amines, smoked and chargrilled foods, and smoking of any kind.
Encourage a dietary intake that is rich in phytonutrients. Food sources containing molybdenum, resveratrol, green tea, quercetin, curcumin, I3C, DIM, and sulforaphane have been shown to be beneficial. In addition, attention should be paid to optimizing phase 2 detoxification.
