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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are Phase I detoxification enzymes that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. CYP21A2 activity is required for the synthesis of steroid hormones including cortisol and aldosterone. 

Genetic variations in this gene are linked to poor cortisol and aldosterone response.  Coleus Forskohlii, phosphatidylserine, sodium levels and the correct mineral ratios have been known to upregulate the CYP21A2 enzyme function.