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Thyroid hormones are essential for the normal metabolic functioning of all tissues in the body. DIO2, (Iodothyronine Deiodinase 2) is one of three genes responsible for thyroid hormone metabolism throughout the body. The deiodinases are the gatekeepers to thyroid hormone bioavailability. DIO2 is the only deiodinase functioning in the brain. The DIO2 gene is involved in thyroid hormone metabolism.

The function of the DIO2 enzyme is the conversion of T4 (thyroxine) to the active thyroid hormone triiodothyronine (T3). The gene’s function is slowed down, leading to an increased risk for:

  1. Reduced thyroid hormone metabolism
  2. Grave’s disease
  3. Osteoarthritis
  4. Psychological disorders
  5. Type 2 diabetes

The TC genotype result is associated with an impaired DIO2 function, slowing the production of the thyroid hormone, T3. You are 35% more likely to develop hypothyroidism.

The rarer CC genotype is found in about 16% of the population and indicates a higher penetrance towards developing hypothyroidism. 

Supplementing with selenocysteine and bile acids provide this enzyme with the nutrient cofactors required for better functioning.