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The FK506 binding protein, encoded by FKBP5, acts as a co-chaperone that modulates not only glucocorticoid receptor activity in response to stressors but also a multitude of other cellular processes in both the brain and periphery. The FKBP5 gene is regulated via complex interactions among environmental stressors, your FKBP5 genetic variant, and epigenetic modifications of glucocorticoid-responsive genomic sites.

If you carry the TT-genotype in this gene then you are predisposed to significantly higher FKBP5 levels and this has been linked to differences in glucocorticoid receptor (GR) sensitivity. The TT genotype has been reported to interact with prior lifetime trauma and/or stress to increase the risk for depression and post-traumatic stress disorder. The SNP provides diagnostic insight for management of individuals exposed to an environmental stressor. Individuals who carry the risk variant may require more intensive follow up after exposure to an environmental stressor. Research has shown that adding in omega 3 can increase expression.