Sort & Filter

GABRA6 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6) is a protein-coding gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. The chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.

The T-allele is the risk allele and is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress.

To optimise the function of the GABRA6, support the production of GABA with:

i. Probiotics (Lactobacillus and Bifidobacterium species produce GABA)

ii. Vitamin B6

iii. Magnesium is also able to bind to and activate GABA receptors.

iv. Taurine (amino acid) binds to GABA receptors (interacts with CBS and SUOX genes)

v. Valeriana officinalis enhances GABAA signaling

vi. Ashwagandha enhances GABAA signaling