GABRA6 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6) is a protein-coding gene.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
The C-allele is the risk allele and is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress.