GSS
The GSS gene ecodes for glutathione synthetase (GSS) is the second enzyme in the glutathione biosynthesis pathway, and important factor in Phase II detoxification. Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and transport of substances across the cell membrane. The protein encoded by this gene functions as a part of the second step of the synthesis of glutathione by the body, which is the conversion of gamma-L-glutamyl-L-cysteine to glutathione, a process which is dependent on the presence of ATP (adenosine triphosphate).
Variations in the GSS gene are a cause of glutathione synthetase deficiency. The following nutrient cofactors can help to up-regulate this enzyme's function:
- Berberine
- Magnesium
- Spirulina
- Alkaline diet
- Copper
Testing pyroglutamic organic acid in your urine can help you to determine whether you have a glutathione deficiency. High levels can indicate a need to "add-in" liposomal/bioavailable glutathione daily.
