The HMOX1 gene encodes the hemeoxygenase enzyme that has both an antioxidant and anti-inflammatory function. This enzyme is considered to be the main protein in diseases arising as a result of oxidative and inflammatory insults. The TT genotype has low HMOX1 activity, thus offering little anti-oxidative and anti-inflammatory protection.
The low activity of HMOX1 with this result may impair:
• Anti-inflammatory response
• Antioxidant defense
• Formation of new blood vessels (angiogenesis)
• Mitochondrial function
• Red blood cell production (erythropoiesis)
• Regulation of cell multiplication (proliferation)
• Regulation of innate and adaptive immunity
• Wound healing
• Iron homeostasis
The TT-allele is considered the risk allele and has been associated with 'leaky GUT' and inflammation of the intestinal tract. If you carry this genotype it is a good idea to add in more nutrient cofactors such as curcumin, omega 3, and resveretrol to upregulate its expression.