This HTR1A gene encodes a G protein-coupled receptor for serotonin (5-hydroxytryptamine) and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene results in behavior consistent with an increased anxiety and stress response. A genetic variation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
The G-allele is associated with depression and therefore it is important to discuss this with your doctor and to make healthy choices that support healthy serotonin levels. Magnesium and calcium increase the binding of serotonin to the 5HT1A receptors. Butyrate increases 5-HT1A receptors in the hypothalamus. Manganese helps 5HT1A activators bind better. Melatonin and Rhodiola increase the number of 5HT1A receptors. St John’s Wort increases the number of postsynaptic 5-HT1A receptors. D3 (dependent on blood tests), can upregulate expression. An omega 3 deficiency is associated with decreased number of 5-HT1A receptors. Eating foods high in tryptophan is important too.
It is important to note that Ashwagandha decreases 5-HT1A signalling.
When looking at your genotype for this gene, it is a good idea to look at the other "mood" genes such as to determine your overall genetic predisposition for depression and mood problems.