IL-6
The IL-6 gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through the interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
IL-6 plays a role in inflammation and is a major regulator of the synthesis of acute-phase reactants by the liver. Adipose tissue is a major source of IL-6, providing up to 30% of the total circulating concentrations in healthy individuals.
Higher circulating IL-6 levels have been associated with obesity and visceral fat deposition, increased risk of impaired glucose tolerance, T2DM, high blood pressure, inflammatory diseases, auto-immune diseases, and certain cancers.
If you carry the GG -allele appears to be associated with raised serum lipids, but may not impact CRP levels. Consider all IL genotypes as well as CRP, TNFA, and HO-1 genotypes when making daily health choices. The CC-allele can predispose you to raised IL-6 and CRP levels. This variant has been linked to obesity and visceral fat, increased risk of impaired glucose tolerance, T2DM, high blood pressure, and several cancers. Consider all IL genotypes as well as CRP, TNFA, and HO-1 genotypes when making daily health choices.
Increase dietary consumption of Curcumin, Omega 3, Vitamin C, Zinc, and CoQ10 to ensure optimisation of this pathway.
