IL-6 plays a role in inflammation and is a major regulator of the synthesis of acute phase reactants by the liver. Adipose tissue is a major source of IL-6, providing up to 30% of the total circulating concentrations in healthy individuals.
Higher circulating IL-6 levels have been associated with obesity and visceral fat deposition, increased risk of impaired glucose tolerance, T2DM, high blood pressure, and certain cancers.
IL-6 is essential for reducing the inflammatory process by promoting the synthesis of anti-inflammatory cytokines and by negatively regulating inflammatory targets. This protein has therefore been classified as having both pro- and anti-inflammatory properties.
If you carry the GG -allele appears to be associated with raised serum lipids, but may not impact CRP levels. Consider all IL genotypes as well as CRP, TNFA and HO-1 genotypes when making daily health choices.
If you carry the CC-allele can cause raised IL-6 and CRP levels. This variant has been linked to obesity and visceral fat, increased risk of impaired glucose tolerance, T2DM, high blood pressure, and several cancers. Increase dietary consumption of omega 3 PUFAs and decrease animal-based saturated fats to ensure optimisation of this pathway. Consider all IL genotypes as well as CRP, TNFA and HO-1 genotypes when making daily health choices.