The IL10 gene encodes for the interleukin 10 protein which is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production.
This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
The following nutrient cofactors have an agonistic effect on IL10 expression (meaning they activate its down-regulating action in the body):
- Caloric restriction
- CBD oil
- Co-enzyme 10
- EPA & DHA
- Aerobic exercise