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The LPL gene provides instructions for making an enzyme called lipoprotein lipase. This enzyme is found primarily on the surface of cells that line tiny blood vessels (capillaries) within muscles and in fatty (adipose) tissue. Lipoprotein lipase plays a critical role in breaking down fat in the form of triglycerides, which are carried from various organs to the blood by molecules called lipoproteins.

Lipoprotein lipase breaks down triglycerides carried by two different types of lipoproteins, which bring fat to the bloodstream from different organs. Fat from the intestine, which is taken in from the diet, is transported to the bloodstream by lipoproteins called chylomicrons. Another type of lipoprotein called very low-density lipoprotein (VLDL) carries triglycerides from the liver into the bloodstream. When lipoprotein lipase breaks down triglycerides, the fat molecules are used by the body as energy or stored in fatty tissue for later use.

Studies have identified associations between the LPL gene and hypertension, insulin resistance, dyslipidemia, obesity, and atherosclerosis.

If you have the C-allele in this gene, then a diet high in fat would not be ideal for you. It would be a good idea to take a polygenic view of your genetic variation in this gene together with with your results for CETP, APOE, APOA5, and APOC3 genotypes.

If you have a G-allele in this gene, then you'll present with increased enzyme activity together with improved triglyceride-rich lipoprotein clearance. G-allele carriers present with lower TG and higher HDL-C levels; which is associated with a beneficial effect on lipid homeostasis, and atheroprotection, contributing to a reduced CVD risk.