The MnSOD or SOD2 gene is vital for antioxidant activity within the cell, especially within the mitochondria. It encodes the genetic pathway responsible for scavenging 'oxidants' (free radicals) and protects cells against oxidative stress. Oxidants can cause DNA and cellular damage, leading to an increase in oxidative stress (high amount of oxidants and their resulting damage). This biochemical action has been linked to accelerated ageing.
If you carry the TT genotype for this gene, then you are predisposed to a decreased function of MnSOD in your mitochondria. In fact, you'll 30-40% less enzyme activity than someone who carries the CC genotype. It's important for you to make choices that protect you form oxidative-stress related problems such as cardiovascular disease and Alzheimer's disease. Manganese is one of the key nutrients required to support this pathway.
The CC genotype has been shown to have a 30 -40% increase in MnSOD activity in your mitochondria. If you have this genotype then you'll notice that you'll have more energy after exercising as research has shown an increase in the MnSod enzyme activity after exercise. You can manage your risk for oxidative stress-related conditions such as chronic fatigue, idiopathic cardiomyopathy, premature ageing, sporadic motor neuron disease, and cancer by avoiding environmental toxins, oxidative stress and increasing your glutathione and phytonutrient intake.