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NFE2L2  is a transcription factor (i.e a molecule that activates the production of a gene product) that in humans is encoded by the NFE2L2 gene. It is central to the action of the body's own endogenous (internal) anti-oxidant production assisting in the activation of the Nrf2 pathway which induces many cytoprotective proteins.

The NFE2L2 protein regulates the expression of the body's antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for the treatment of diseases that are caused by oxidative stress. The NFE2L2 transcription factor regulates genes that contain antioxidant response elements (ARE); many of these genes encode proteins involved in response to injury and inflammation that result in the production of free radicals. 

The following nutrient cofactors have an agonist impact on the NFE2L2 protein, upregulating its activity:

  • Sulforaphane
  • Broccoli sprouts
  • Butyric acid
  • Ginseng Panax
  • Curcumin
  • Daphnetin
  • Melatonin
  • Pterostilbene