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NOS3 produces the enzyme nitric oxide synthase responsible for making nitric oxide, known to be protective in our blood vessels and to be involved in vasodilation (opening of the blood vessels).

Variants result in low nitric oxide production which has been associated with cardiovascular disease. Recent research has shown that omega-3 fat has a positive impact on cardiovascular risk in people with NOS3 variants by lowering another kind of fat called triglycerides which is also linked to lower HDL (good) cholesterol.