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Oxytocin is a peptide hormone and neuropeptide that is involved in the regulation of mood, anxiety, and social biology. It plays a role in social bonding, sexual reproduction in both sexes, and during and after childbirth. The protein encoded by the OXTR gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

If you carry the AA allele then you are predisposed to a change in OXTR function such that there is decreased sensitivity to social cues, especially in a stressful environment.

Individuals with the AG genotype may have a lower empathetic ability and a decreased ability to manage stressful situations, with an increased risk for post-traumatic stress disorder, especially with exposure to adverse childhood events. Individuals who carry the risk variant may require more intensive follow-up after exposure to an environmental stressor.

Nutrients, minerals, and probiotics that are necessary for normal oxytocin production and functioning include:

i. Vitamin C - cofactor for oxytocin production

ii. Magnesium - required for proper oxytocin functioning

iii. Probiotics: improve microbiome (Lactobacillus reuteri)