The PDE8B gene is a key regulator of many important physiological processes. It is involved in the specific signaling of TSH (thyroid stimulating hormone) in the thyroid gland.
PDE8B plays a role in the following:
- Thyroid function and helps determine the level of TSH. Higher PDE8B should cause lower TSH.
- In Alzheimer's disease, PED8B is increased in certain brain regions.
- Insulin secretion
- Adrenal disorders
The GG-genotype is associated with lower TSH. Some research indicates that both zinc and magnesium provide cofactor support to the enzyme encoded by this gene.