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The PDE8B gene is a key regulator of many important physiological processes. It is involved in the specific signaling of TSH (thyroid stimulating hormone) in the thyroid gland.

PDE8B plays a role in the following:

  • Thyroid function and helps determine the level of TSH.  Higher PDE8B should cause lower TSH.  
  • In Alzheimer's disease, PED8B is increased in certain brain regions.
  • Insulin secretion
  • Adrenal disorders

The GG-genotype is associated with lower TSH. Some research indicates that both zinc and magnesium provide cofactor support to the enzyme encoded by this gene.