Phosphatidylethanolamine N-Methyltransferase (PEMT) is an enzyme encoded for by the PEMT gene which is responsible for the conversion of phosphatidylethanolamine (PE) into phosphatidylcholine (PC) in the liver. PC is a key component of the flexible cell membranes which surround every cell in our body and therefore plays an important role in cellular defence.
Most of your PC comes from your diet, however, PEMT is able to synthesise PC directly meaning it is thought to play an important role in providing PC during times of starvation. As part of its activity PEMT produces homocysteine, which plays an important role in the MTHFR gene-related health issues. It is therefore important for you to consider both your PEMT and MTHFR genotypes to determine your overall function.
PEMT activity is especially important in the liver and brain which require large amounts of PC, and choline which is derived from PC breakdown, to maintain normal function.
The A-allele in this gene predisposes you to decreased phosphatidylcholine, slower bile flow, muscle function, liver, and brain function. It is important for you to add in 400 mg choline, green tea, and SAMe to your daily health choices. This is especially true for women after menopause or if your homocysteine levels are high and you carry this genetic variation.