PPARs affect the expression of target genes involved in cell proliferation, cell differentiation, and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor.
mainly expression in the kidney, and heart. PPARA is involved in the uptake, utilisation, and breakdown of fatty acids to ‘ATP’ - the main source of energy during prolonged exercise.