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The SIRT(Sirtuin 1-4) gene encodes for the sirtuin family of proteins. Diseases associated with SIRT include periapical periodontitis and ageing.  

SIRT is involved in the following super-pathways - NAD metabolism, the longevity pathway and AMPK signaling pathway. 

Resveratrol is a natural compound that activates SIRT, and may help in the treatment or prevention of obesity, and in preventing tumorigenesis and the aging-related decline in heart function and neuronal loss. NAD+ is a co-factor for Sirt1 deacetylase activity, which links Sirt1 action to metabolic conditions, like nutrient shortage or increased mitochondrial respiration. Niacin (B3) is also a nutrient co-factor for the SIRT enzyme. 

The following foods that can activate SIRT include kale, fish oil, green tea, black currants, turmeric, citrus fruits, parsley, extra virgin olive oil, olives, apples, and dark chocolate. All these foods can be found in the Functional Medicine Mito-Food Plan. 

An APOE4 genetic variation together with SIRT can indicate a predisposition for cognitive decline.