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This SLC6A4 gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons.

SLC6A4 is a Protein Coding gene. Diseases associated with SLC6A4 include obsessive-compulsive disorder, anxiety, and fibromyalgia. Among its related pathways are the circadian rhythm related genes and the synaptic vesicle cycle.

The C-allele is associated with depression. It is recommended that you check your plasma serotonin metabolites under the care of your doctor. Eating foods high in tryptophan could help with regulating serotonin as it is a precursor to the neurotransmitter serotonin, the hormone melatonin, and vitamin B3.