The process of oxidation happens as our bodies metabolise the oxygen that we breathe and our cells produce energy from it. This process also produces free radicals –which interact with the molecules within our cells resulting in damage (or stress) to nearby cells, mitochondria, and DNA (our genes).
Free radicals are normal and necessary to some degree. In addition to causing some damage, they also stimulate repair. It is only when the amount of free radicals produced overwhelms the repair processes that it becomes an issue. That is what we call oxidative stress.