TNF-α is a potent immune-mediator and pro-inflammatory cytokine. TNF-α plays a powerful role in regulating inflammatory pathways. Chronic low-grade systemic inflammation has been introduced as a term for conditions in which there is a two- to three-fold increase in the systemic concentrations of several cytokines. The inflammatory state is a major component of obesity and its associated comorbidities, such as CVD, T2DM, Alzheimer's Disease, and several cancers.
In addition, increased production of TNF-α is a crucial mediator of insulin resistance (IR), inflammatory bowel disease, dyslipidemia, and rheumatoid arthritis. Genetic variations in the TNFA gene may affect TNF-α transcription and expression, influencing the development of conditions associated with increased TNF-α production. Dietary factors, such as fatty acids, interact with TNFA gene variants and modulate the development and progression of inflammatory-related conditions.
If you have the A-allele carrier status in this gene, then you are predisposed to increases TNF-α transcription two-fold, with a subsequent increase in TNF-α production. This has been associated with low-grade, chronic inflammation and associated conditions. Specifically, with overweight and obesity, insulin resistance, inflammatory bowel disease, dyslipidemia, and all arthritis conditions.
It 's a good idea to reduce linoleic and arachidonic acid in your diet and increase omega 3 intake. When personalising your health choices, it is important to consider your IL-1, IL-6, and APOE genotypes.