Urinary neurotransmitter testing provides an overall assessment of the body’s ability to make and break down neurotransmitters and is representative of whole-body levels. Neurotransmitters are secreted all through the body, in neurons of both the central and peripheral nervous systems. The enzymes, cofactors, and precursors in neurotransmitter metabolism in general are the same in the periphery and in the central nervous system.
Therefore, alterations in urinary neurotransmitter levels assessed in urine provide important clinical information and may be associated with many symptoms including cognitive and mood concerns, diminished drive, fatigue and sleep difficulties, cravings, addictions, and pain. Associations between urinary neurotransmitter levels and health conditions have been documented in scientific literature and may provide valuable insights as part of a comprehensive health assessment.
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- Mood concerns, such as depression, anxiety
- Diminished energy/fatigue
- Cognitive concerns such as forgetfulness, inattention, brain fog
- Addiction, dependency
- Obsessions and cravings
- Chronic illness, immune deficiency
- Low libido, sexual dysfunction
Analysis of urinary neurotransmitters is non-invasive; testing may provide therapeutic opportunities that improve clinical success and patient health outcomes.
Neurotransmitters are secreted from pre-synaptic neurons into the synapse between nerve cells to stimulate receptors on post-synaptic neurons. The neurotransmitters are all produced from essential aromatic amino acids. Neurotransmitter metabolism may be mediated by a variety of enzymes expressed differently throughout the body. Circulating levels of neurotransmitters and metabolites may have distinctive sources.
A lack of nutritional cofactors (vitamins, minerals) required for normal enzyme function may decrease enzyme function and neurotransmitter levels. Neurotransmitter receptors and metabolic enzymes may be subject to mutations and single nucleotide polymorphisms (SNPs) that may affect receptor or enzyme function. Normal neurotransmitter receptor function is also necessary for normal neurotransmitter activity. Neurotransmitter levels may be influenced by many factors, such as diet, lifestyle, age, sex, body mass index, hormone imbalance, environmental exposures, infection, chronic inflammation, and nicotine use.
Neurotransmitter analysis provides an overall assessment of a patient’s ability to synthesize and metabolize neurotransmitters, which must occur in both the peripheral nervous system and behind the blood-brain barrier (BBB). Alterations in urinary neurotransmitter status may result from a variety of conditions including metabolic disorders, mood/behavioral disorders, environmental exposures, or (rarely) the presence of certain tumors. Evaluation of neurotransmitters may provide increased clarity about a patient’s health and functional status.
Information gained through neurotransmitter testing may provide therapeutic opportunities that improve clinical success and patient health outcomes. Associations between urinary neurotransmitter levels and health conditions have been documented in scientific literature and may provide valuable insight as part of a comprehensive health assessment.
If you suspect that you have kidney damage or compromised renal function, a 24-hour collection is a better option to accurately assess the excretion of the neurotransmitters.