The ADRB3 gene is a candidate gene for obesity because of the role it plays in energy expenditure regulation. ADRB3 is involved in the regulation of lipolysis and thermogenesis in both brown and white adipose tissue. The SNP is associated with abdominal obesity, insulin resistance, earlier onset of T2DM, and a tendency to have a lower metabolic rate or resting energy expenditure and hence an increased capacity to gain weight. The risk of obesity appears to occur at a younger age.
If you carry a risk variant in this gene, then you are predisposed towards a decreased lipolytic sensitivity, thermogenesis, and lipolysis. This can result in increased abdominal obesity, greater weight gain, insulin resistance, and decreased energy expenditure. This means that you need to lead an active lifestyle with high-intensity levels to impact weight management goals. When adopting more personalised health choices, it is important for you to consider your ADRB2 genotypes.