CYP17A
The cytochrome P450 proteins are mono-oxygenases that catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
The CYP17A gene mediates both steroid 17α-hydroxylase and 17,20-lyase activities and catalyses a rate-limiting step in ovarian and adrenal biosynthesis leading to the precursor, dehydroepiandrosterone (DHEA).
The C allele increases enzyme activity, thereby increasing the amount of bioavailable estrogen. For individuals with the C allele beneficial modulation of estrogen metabolism can be accomplished through dietary and lifestyle modifications.
If you carry the C-allele increase insoluble fiber, avoid refined carbohydrates, increase phytoestrogens, achieve and maintain an ideal weight, and increase exercise.
