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The cytochrome P450 proteins are mono-oxygenases that catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.

The CYP17A gene mediates both steroid 17α-hydroxylase and 17,20-lyase activities and catalyses a rate-limiting step in ovarian and adrenal biosynthesis leading to the precursor, dehydroepiandrosterone (DHEA).

The C allele increases enzyme activity, thereby increasing the amount of bioavailable estrogen. For individuals with the C allele beneficial modulation of estrogen metabolism can be accomplished through dietary and lifestyle modifications.

If you carry the C-allele increase insoluble fiber, avoid refined carbohydrates, increase phytoestrogens, achieve and maintain an ideal weight, and increase exercise.