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CYP1A2 encodes for the Cytochrome P450 1A2 enzyme. This enzyme is the main caffeine metabolizing enzyme and is involved in the metabolism of xenobiotics in the body.

Expression of CYP1A2 appears to be induced by various dietary constituents. Vegetables such as cabbages, cauliflower, and broccoli are known to increase levels of CYP1A2 as these foods contain high levels of the chemical messengers  IC3, DIM, and sulforaphane. Curcumin is also known to act as a nutrient co-factor in this pathway.