CYP1B1
The CYP1B1 gene provides instructions for producing the cytochrome P450 1B1 enzyme that is a member of the cytochrome P450 family of enzymes. These enzymes are involved in many processes in the body, such as assisting with reactions that break down drugs and produce certain fats (lipids). Interestingly, CYP1B1 is one of the main enzymes that are required in the hydroxylation of estrogens and the activation of some carcinogens. CYP1B1 mediates the metabolic activity of many procarcinogens.
If you carry the C-allele in this gene, then you are predisposed to greater 4-hydroxylase activity and you would need to make nutrigenomic choices to downregulate this enzyme's activity. This genetic variation has been linked with an increased risk for prostate, breast, and ovarian cancer.
Medium to high impact variations in this gene means that you should reduce exposure to all diet and environmental procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) which are a group of more than 100 different chemicals that are released from burning coal, oil, gasoline, trash, tobacco, wood, or other organic substances such as charcoal-broiled meat. It's also a good idea to avoid nitrates that can be found in processed foods and meats and smoking of any kind. Ensure optimal phase 2 detoxification. Bioactive sulforaphane, DIM, and I3C are useful in inhibiting CYP1B1 and upregulating phase 2 liver detox.
