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The FTO (fat-mass-and-obesity-associated)  gene is present at high levels in several metabolically active tissues, including, heart, kidney, and adipose tissue, and is most highly expressed in the brain, particularly in the hypothalamus which is concerned with the regulation of arousal, appetite, temperature, autonomic function, and endocrine systems. It has been suggested that the FTO gene plays a role in appetite regulation and that it is associated with energy expenditure, energy intake, and diminished satiety.

The A allele has been associated with higher BMI, body fat percentage and waist circumference, especially in individuals with a sedentary lifestyle and a high fat intake. Modify the diet to include a moderate amount of carbohydrate, increase MUFA and decrease SAT FAT, and manage the total fat intake. Regular physical activity is recommended.