The IL1RN gene is involved in the regulation of inflammatory responses. Osteoarthritis is the most common type of arthritis. It is associated with continuous breakdown of the cartilage, pain, stiffness and eventually, decreased motion range of affected joints. It is regarded as the greatest cause of disability between elderly population worldwide. Although, some patients show a relatively stable course with slight symptomatic changes with time, others, rapidly develop severe structural disability leading to joint replacement. Gene mutations in the IL1RN gene can contribute to this.
The CC genotype is associated with enhanced inflammatory activity.
A diet or supplementation protocol high in omega-3 (DHA), curcumin, chondroitin, glucosamine and collagen can provide healing and supportive nutrients to this genetic pathway.