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The PLIN gene proteins were discovered in the adipocyte (fat cells), where they regulate lipid storage and lipolysis. This gene's main area of function is the regulation of lipid storage and lipolysis in adipocytes (fat cell). It influences how you lose weight and can result in insulin resistance and poor triglyceride metabolism. 

An A-allele variation in this gene can result in reduced perilipin expression, dysregulation in lipid storage and lipolysis in adipocytes. The potential resistance to weight loss resulting in associated obesity, and insulin resistance. This allele is associated with greater obesity risk. A allele carriers are more weight loss resistant and show a greater decrease in lipid oxidation rate than GG. When there is a higher intake of complex CHO, the allele is protective against obesity. Avoid all refined CHO.