The PPARG gene (Peroxisome proliferator-activated receptor gamma) is believed to be involved in fat cell differentiation. It is a protein-messenger that is activated by fatty acids, which has a major role in the production of fat and expression of fat cell-specific genes. It is also involved in the regulation of glucose and lipid metabolism and has been identified as the nuclear receptor for the thiazolidinedione class of insulin-sensitizing drugs.
The CC genotype is highly sensitive to the type and amount of fat in the diet, with regards susceptibility to obesity and diabetes. An increase in total dietary fat and saturated fat has been associated with increased waist circumference in CC individuals. Attention should be paid to the quality of fat intake, increasing MONO-UNSATURATED FAT in the diet and decreasing SATURATED FAT.
Individuals with CC-allele are also at risk for increased inflammation and oxidative stress if overweight.