The SULT1A1 gene encodes Sulfotransferase Enzymes Catalyze, the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. This gene is broadly expressed in the duodenum, liver and 22 other tissues.
SULT1A1 is involved in the inactivation of estrogens and bioactivation of heterocyclic amines (which form when meat, poultry, and seafood are cooked at a high temperature. Frying, broiling, and grilling produce the largest amounts of these compounds) and polycyclic aromatic hydrocarbons ( a group of more than 100 different chemicals that are released from burning coal, oil, gasoline, trash, tobacco, wood, or other organic substances such as charcoal-broiled meat).
Medium to high genetic variations in this gene can result in a slower pathway. Therefore it is important to provide nutritional support this phase 2 liver pathway as well as avoid making toxic, environmental choices.