CYP1B1

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Shop nutrigenomic products that provide targeted nutrition to support this genetic pathway. Involved in Phase 2 liver detoxification and in the oxidative metabolism of estrogens.

The CYP1B1 gene provides instructions for producing an enzyme that is a member of the cytochrome P450 family of enzymes. These enzymes are involved in many processes in the body, such as assisting with reactions that break down drugs and produce certain fats (lipids). 

If you carry the C-allele in this gene, then you are predisposed to greater 4-hydroxylase activity. This genetic variation has been linked with an increased risk for prostate, breast and ovarian cancer.

Medium to high impact variations in this gene means that you should reduce exposure to all diet and environmental procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) which are a group of more than 100 different chemicals that are released from burning coal, oil, gasoline, trash, tobacco, wood, or other organic substances such as charcoal-broiled meat. So this means no braais! It's also a good idea to avoid nitrates that can be found in processed foods and meats and smoking of any kind. Ensure optimal phase 2 detoxification. Bioactive sulforaphane is useful in inhibiting CYP1B1 and upregulating phase 2 liver detox.